Recommended reading

Check-Direct CPE

Multicentre evaluation of the Check-Direct CPE® assay for direct screening of carbapenemase-producing Enterobacteriaceae from rectal swabs.
Huang TD, Bogaerts P, Ghilani E, Heinrichs A, Gavage P, Roisin S, Willems E, Verbruggen AM, Francart H, Denis O, Senterre JM, Glupczynski Y.

J Antimicrob Chemother. Published online ahead of print 2015 Jan 29.

To the publication

Check-MDR CT103

Evaluation of Check-Points Check-MDR CT103 PCR-Microarray Kit for Detection and Classification of ESBL, AmpC and Carbapenemase Genes.
Cunningham SA, Johnston B, Vasoo S, Johnson J, Patel R.

Presented at: 54th ICAAC; 2014 Sept 5 -9; Washington, DC.

To the publication

Check-Direct CPE

Comparison of the Check-Direct CPE real-time PCR kit to selective agar media for the detection of carbapenemases in Enterobacteriaceae.
Eigner U, Veldenzer A, Hefner N, Schwarz R, Holfelder M.

Presented at: 25th ECCMID, 25-28 April 2015, Copenhagen, Denmark.

To the publication

 


Check-Direct

Check-Direct CPE

Huang TD, Bogaerts P, Ghilani E, Heinrichs A, Gavage P, Roisin S, Willems E, Verbruggen AM, Francart H, Denis O, Senterre JM, Glupczynski Y. Multicentre evaluation of the Check-Direct CPE® assay for direct screening of carbapenemase-producing Enterobacteriaceae from rectal swabs. J Antimicrob Chemother. Published online ahead of print 2015 Jan 29. Learn more

Findlay J, Hopkins KL, Meunier D, Woodford N. Evaluation of three commercial assays for rapid detection of genes encoding clinically relevant carbapenemases in cultured bacteria. J Antimicrob Chemother. Published online ahead of print 2015 Jan 27. Learn more

Op Den Buijs I et al. Molecular screening for ESBL and carbapenemase during a prevalence study in two Dutch hospitals. Presented at: 26th ECCMID, 9-12 April 2016, Amsterdam, The Netherlands. Learn more

Österblad M, Lindholm L, Jalava J. Evaluation of two commercial carbapenemase gene assays, the Rapidec Carba NP test and the in-house Rapid Carba NP test, on bacterial cultures. J Antimicrob Chemother. 2016 Mar 31. Published online ahead of print Learn more

Otter J, Goldenberg S, Walker C, Patel A, Edgeworth J, Ahanonu C, Tosas Auguet O, Querol-Rubiera A, Girdham S, Bisnauthsing K. Universal admission screening for CRE using PCR detects 14-fold more carriers than agar-based methods at a London hospital. Presented at: 25th ECCMID, 25-28 April 2015, Copenhagen, Denmark. Learn more

Lau AF, Fahle GA, Kemp MA, Jassem AN, Dekker JP, Frank KM. Clinical Performance of Check-Direct CPE, a Multiplex PCR for Direct Detection of blaKPC, blaNDM/VIM, and blaOXA48 from Perirectal Swabs. J Clin Microbiol. 2015 Dec;53(12):3729-37. Learn more

Eigner U, Veldenzer A, Hefner N, Schwarz R, Holfelder M. Comparison of the Check-Direct CPE real-time PCR kit to selective agar media for the detection of carbapenemases in Enterobacteriaceae. Presented at: 25th ECCMID, 25-28 April 2015, Copenhagen, Denmark. Learn more

Meunier D, Hopkins K, Findlay J, Woodford N. Evaluation of the Check-Direct CPE assay for detecting carbapenemase genes in multidrug-resistant Gram-negative bacteria. Presented at: 25th ECCMID, 25-28 April 2015, Copenhagen, Denmark. Learn more

Wohlwend N, Pires J, Droz S, Endimiani A, Risch L, Risch M, Bodmer T. Rapid screening for ESBL and carbapenemase genes by real-time PCR using the check-direct on the BD MAX™ open mode platform. Presented at: 25th ECCMID, 25-28 April 2015, Copenhagen, Denmark. Learn more

Saegeman V, Van den Eynde J, Niclaes L, De Ridder D, Schuermans A, Glupczynski Y. Performance of different culture methods and of a commercial molecular assay for the detection of carbapenemase-producing Enterobacteriaceae in nursing homes and rehabilitation centers. Eur J Clin Microbiol Infect Dis. Published online ahead of print 2015 Jan 21. Learn more

Nijhuis R, Samuelsen Ø, Savelkoul P, van Zwet A. Evaluation of a new real-time PCR assay (Check-Direct CPE) for rapid detection of KPC, OXA-48, VIM and NDM carbapenemases using spiked rectal swabs. Diagn Microbiol Infect Dis. 2013 Dec;77(4):316-20. Learn more

Bogaerts P, Delwiche D, Huang T-D, Francart H, Verbruggen A-M, Glupczynski Y. Real-Time PCR Assays for the Detection of Carbapenemase-Producing Enterobacteriaceae (CPE) from Stool Samples. Presented at: 53rd ICAAC, 2013 September 12th, Denver, CO. Learn more

Bullivant J, Smedley C, Davies S, Davis S, Parsons H. Comparison of Check-Point PCR to Multi-Resistant Gram Negative Screening Media for the detection of Carbapenemase Producing Enterobacteriaceae. Presented at: HIS & IPS Spring Meeting 2014, Birmingham, UK. Learn more

Nijhuis RHT, Savelkoul PHM, van Zwet AA. Carbapenemase producing bacteria in travellers constitute a potential threat for current hospital infection control programs. Presented at: 24th ECCMID, 10-13 May 2014, Barcelona, Spain. Learn more

Williams A, Vanstone G, Balakrishnan I. Direct Detection of carbapenemase-producing Enterobacteriaceae and Pseudomonas spp. from positive blood cultures. Presented at: BSAC Spring Meeting, 20 March 2014, London, UK. Learn more

Eigner U, Veldenzer A, Holfelder M. Validation of the new real-time PCR kit Check-Direct CPE for the detection of KPC, NDM/VIM and OXA-48 in Enterobacteriaceae. Presented at: 66th DGHM, 5-8 October 2014, Dresden, Germany. Learn more


Check-Direct ESBL

Op Den Buijs I et al. Molecular screening for ESBL and carbapenemase during a prevalence study in two Dutch hospitals. Presented at: 26th ECCMID, 9-12 April 2016, Amsterdam, The Netherlands. Learn more

Slotboom B et al. A multi-centre prospective evaluation of the Check-Direct ESBL Screen™ as a rapid molecular screening method for extended-spectrum beta-lactamase producing Enterobacteriaceae rectal carriage. Presented at: 26th ECCMID, 9-12 April 2016, Amsterdam, The Netherlands. Learn more

Humaun Kabir M et al. Evaluation of check-direct ESBL real-time PCR kit for the detection of ESBL-producing Enterobacteriaceae from fecal sample. Presented at: 26th ECCMID, 9-12 April 2016, Amsterdam, The Netherlands. Learn more

Wohlwend N, Pires J, Droz S, Endimiani A, Risch L, Risch M, Bodmer T. Rapid screening for ESBL and carbapenemase genes by real-time PCR using the check-direct on the BD MAX™ open mode platform. Presented at: 25th ECCMID, 25-28 April 2015, Copenhagen, Denmark. Learn more


Check-MDR

Check-MDR Carba

Hanemaaijer NM, Nijhuis RH, Slotboom BJ, Mascini EM, van Zwet AA. New screening method to detect carriage of carbapenemase-producing Enterobacteriaceae in patients within 24 hours. J Hosp Infect. 2014 May;87(1):47-9. Learn more

Cuzon G, Naas T, Bogaerts P, Glupczynski Y, Nordmann P. Probe ligation and real-time detection of KPC, OXA-48, VIM, IMP, and NDM carbapenemase genes. Diagn Microbiol Infect Dis. 2013 Aug;76(4):502-5. Learn more


Check-MDR ESBL

Nijhuis R, van Zwet A, Stuart JC, Weijers T, Savelkoul P. Rapid molecular detection of extended-spectrum β-lactamase gene variants with a novel ligation-mediated real-time PCR. J Med Microbiol. 2012 Nov;61(Pt 11):1563-7. Learn more

Willemsen I, Hille L, Vrolijk A, Bergmans A, Kluytmans J. Evaluation of a commercial real-time PCR for the detection of extended spectrum β-lactamase genes. J Med Microbiol. 2014 Apr;63(Pt 4):540-3. Learn more


Check-MDR CT103 XL

Cunningham SA, Vasoo S, Patel R. Evaluation of the Check-Points Check MDR CT103 and CT103 XL Microarray Kits Using Preparatory Rapid Cell Lysis. J Clin Microbiol. 2016 Feb 17. Published online ahead of print Learn more

Suwantarat N, Carroll KC, Rudin S, Marshall SH, Tekle T, Ross T, Logan LK, Conley A, Bonomo RA, Tamma PD. Multi-drug Resistant Gram-negative Organisms in the Pediatric Intensive Care Unit (PICU). Presented at: 115th ASM General Meeting, 30 May - 2 June 2015, New Orleans, Louisiana. Learn more

Schwenk S. Platt G, Personne Y, Grgic L, Gant V, Zumla A, Enne V. Checking up on resistance: aphenotypic and genotypic analysis of extended spectrum beta-lactamase and carbapenemase-producing Enterobacteriaceae. Presented at: 25th ECCMID, 25-28 April 2015, Copenhagen, Denmark. Learn more


Check-MDR CT102

Woodford N, Warner M, Pike R, Zhang J. Evaluation of a commercial microarray to detect carbapenemase-producing Enterobacteriaceae. J Antimicrob Chemother. 2011 Dec;66(12):2887-8. Learn more

Naas T, Cuzon G, Bogaerts P, Glupczynski Y, Nordmann P. Evaluation of a DNA microarray (Check-MDR CT102) for rapid detection of TEM, SHV, and CTX-M extended-spectrum β-lactamases and of KPC, OXA-48, VIM, IMP, and NDM-1 carbapenemases. J Clin Microbiol. 2011 Apr;49(4):1608-13. Learn more

Cohen Stuart J, Voets G, Scharringa J, Fluit A, Leverstein-Van Hall M. Detection of carbapenemase producing Enterobacteriaceae with a commercial DNA Microarray. J Med Microbiol. 2012 Jun;61(Pt 6):809-12. Learn more

Eigner U, Bertsch D, Moskorz K, Holfelder M. Evaluation of a low-density microarray for the identification of ESBL, AmpC and carbapeneamase-producing Enterobacteriaceae. Poster session presented at: 21st ECCMID; 2011 May 7-10; Milan, Italy. Learn more

Somily AM, Arshad MZ, Garaween GA, Senok AC. Phenotypic and genotypic characterization of extended-spectrum b-lactamases producing Escherichia coli and Klebsiella pneumoniaein a tertiary care hospital in Riyadh, Saudi Arabia. Ann Saudi Med. 2015 Nov-Dec;35(6):435-9. Learn more

Somily AM, Garaween GA, Abukhalid N, Absar MM, Senok AC. Comparison of Molecular and Phenotypic Methods for the Detection and Characterization of Carbapenem Resistant Enterobacteriaceae. Acta Microbiol Immunol Hung. 2016 Mar;63(1):69-81. Learn more


Check-MDR CT101

Castanheira M, Mills JC, Costello SE, Jones RN, Sader HS. Ceftazidime-Avibactam Activity Tested against Enterobacteriaceae Isolates from U.S. Hospitals (2011 to 2013) and Characterization of β-Lactamase-Producing Strains. Antimicrob Agents Chemother. 2015 Jun;59(6):3509-17. Learn more

Bogaerts P, Hujer AM, Naas T, de Castro RR, Endimiani A, Nordmann P, Glupczynski Y, Bonomo RA. Multicenter evaluation of a new DNA microarray for rapid detection of clinically relevant bla genes from beta-lactam-resistant gram-negative bacteria. Antimicrob Agents Chemother. 2011 Sep;55(9):4457-60. Learn more

Roberts AA, Tekle T, Stamper PD, Carroll KC. Evaluation of a PCR-Microarray Assay (Check-MDR CT101, Wageningen, The Netherlands) for the Detection of Carbapenemase-Producing Enterobacteriaceae. Poster session presented at: 111th ASM; 2011 May 21-24; New Orleans, US. Learn more

Castanheira M, Farrell SE, Deshpande LM, Mendes RE, Jones RN. Prevalence of β-lactamase encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 USA hospitals: Report from the SENTRY Antimicrobial Surveillance Program (2010). Antimicrob Agents Chemother. 2013 Jul;57(7):3012-20. Learn more

Lascols C, Hackel M, Marshall SH, Hujer AM, Bouchillon S, Badal R, Haban D, Bonomo RA. Increasing prevalence and dissemination of NDM-1 metallo-β-lactamase in India: data from the SMART study (2009). J Antimicrob Chemother. 2011 Sep;66(9):1992-7. Learn more

De Boeck H, Lunguya O, Muyembe JJ, Glupczynski Y, Jacobs J. Presence of extended-spectrum beta-lactamase-producing Enterobacteriaceae in waste waters, Kinshasa, the Democratic Republic of the Congo. Eur J Clin Microbiol Infect Dis. 2012 Nov;31(11):3085-8. Learn more


Previous products

Check-MDR CT103

Cunningham SA, Vasoo S, Patel R. Evaluation of the Check-Points Check MDR CT103 and CT103 XL Microarray Kits Using Preparatory Rapid Cell Lysis. J Clin Microbiol. 2016 Feb 17. Published online ahead of print Learn more

Cuzon G, Naas T, Bogaerts P, Glupczynski Y, Nordmann P. Evaluation of a DNA microarray for the rapid detection of extended- spectrum ß-lactamases (TEM, SHV and CTX-M), plasmid-mediated cephalosporinases (CMY-2-like, DHA, FOX, ACC-1, ACT/MIR and CMY-1-like/MOX) And carbapenemases (KPC, OXA-48, VIM, IMP, and NDM). J Antimicrob Chemother. 2012 Aug;67(8):1865-9. Learn more

Willemsen I, van Esser J, Kluytmans-van den Bergh M, Zhou K, Rossen JW, Verhulst C, Verduin K, Kluytmans J. Retrospective identification of a previously undetected clinical case of OXA-48-producing K. pneumoniae and E. coli: the importance of adequate detection guidelines. Infection. 2016 Feb;44(1):107-10. Learn more

Cunningham SA, Johnston B, Vasoo S, Johnson J, Patel R. Evaluation of Check-Points Check-MDR CT103 PCR-Microarray Kit for Detection and Classification of ESBL, AmpC and Carbapenemase Genes. Presented at: 54th ICAAC; 2014 Sept 5 -9; Washington, DC. Learn more

Juiz P, Solé M, Pitart C, Marco F, Almela M, Vila J. Detection of extended-spectrum β-lactamase- and/or carbapenemase-producing Enterobacteriaceae directly from positive blood culture using a commercialised microarray technique. Int J Antimicrob Agents. 2014 Jul;44(1):88-9. Learn more

Pancholi P, Faubel R, Thomas K, Smith D, Balada-Llasat JM. Rapid detection of extended-spectrum beta-lactamases, plasmid-mediated cephalosporinases (AmpC) and carbapenemases directly from blood cultures by use of a nucleic acid DNA microarray. Presented at: 24th ECCMID; 2014 May 10-13; Barcelona, Spain. Learn more


Check-KPC ESBL

Fishbain JT, Sinyavskiy O, Riederer K, Hujer AM, Bonomo RA. Detection of Extended Spectrum β-Lactamase (ESBL) and Klebsiella pneumoniae Carbapenemase (KPC) Genes Directly from Blood Cultures Using a Nucleic Acid Microarray. J. Clin. Microbiol. 2012 Sept;50(9):2901-2904. Learn more

Willemsen I, Overdevest I, al Naiemi N, Rijnsburger M, Savelkoul P, Vandenbroucke-Grauls C, Kluytmans J, on behalf of the TRIANGLe study group. New diagnostic microarray (Check-KPC ESBL) for detection and identification of extended-spectrum beta- lactamases in highly resistant Enterobacteriaceae. J. Clin. Microbiol. 2011 Aug;49(8):2985-7. Learn more

Platteel TN, Stuart JW, Voets GM, Scharringa J, van de Sande N, Fluit AC, Leverstein-Van Hall MA; ESBL national surveillance working group. Evaluation of a commercial microarray as a confirmation test for the presence of extended-spectrum β-lactamases in isolates from the routine clinical setting. Clin Microbiol Infect. 2011 Sep;17(9):1435-8. Learn more

Endimiani A, Hujer AM, Hujer KM, Gatta JA, Schriver AC, Jacobs MR, Rice LB, Bonomo RA. Evaluation of a commercial microarray system for detection of SHV-, TEM-, CTX-M-, and KPC-type beta-lactamase genes in Gram-negative isolates. J. Clin. Microbiol. 2010 Jul;48(7):2618-22. Learn more

Naas T, Cuzon G, Truong H, Bernabeu S, Nordmann P. Evaluation of a DNA microarray, the Check-Points ESBL/KPC array, for rapid detection of TEM, SHV, and CTX-M extended-spectrum beta-lactamases and KPC carbapenemases. Antimicrob Agents Chemother. 2010 Aug;54(8):3086-92. Learn more

Granier SA, Gousset M, Grout J, Brisabois A. Check-KPC ESBL method to detect ESBL carrying Salmonella. Poster session presented at: 30th RICAI; 2010 Dec 2-3; Paris, France. Learn more

Lascols C, Badal R, Hoban D, Cruz C, Szewczyk K, Hackel M, Hawser S, Bouchillon S and Johnson J. A Novel DNA Microarray Method for Rapid Detection and Identification of Extended-spectrum β-lactamases (ESBLs) and KPC in Enterobacteriaceae. Poster session presented at: 110th ASM; 2010 May 23-27; San Diego, US. Learn more

Lascols C, Hackel M, Hujer AM, Marshall SH, Bouchillon SK, Hoban DJ, Hawser SP, Badal RE, Bonomo RA. Using Nucleic Acid Microarrays to Perform Molecular Epidemiology and Detect Novel β-Lactamases: a Snapshot of ESBLs Throughout the World. J Clin Microbiol. 2012 May;50(5):1632-9. Learn more


Check-ESBL

Schoevaerdts D, Bogaerts P, Grimmelprez A, de Saint-Hubert M, Delaere B, Jamart J, Swine C, Glupczynski Y. Clinical profiles of patients colonized or infected with extended-spectrum beta-lactamase producing Enterobacteriaceae isolates: a 20 month retrospective study at a Belgian University Hospital. BMC Infect Dis. 2011 Jan 12;11:12. Learn more

Cohen Stuart J, Dierikx C, Al Naiemi N, Karczmarek A, Van Hoek AH, Vos P, Fluit AC, Scharringa J, Duim B, Mevius D, Leverstein-Van Hall MA. Rapid detection of TEM, SHV and CTX-M extended-spectrum beta-lactamases in Enterobacteriaceae using ligation- mediated amplification with microarray analysis. J Antimicrob Chemother. 2010 Jul;65(7):1377-81. Learn more

Nijhuis RH, van Zwet AA, Savelkoul PH, Roovers EA, Bosboom RW, Postma B, van Griethuysen AJ. Distribution of extended- spectrum beta-lactamase genes using a commercial DNA micro-array system. J Hosp Infect. 2011 Dec;79(4):349-53. Learn more

Wintermans BB, Reuland EA, Wintermans RG, Bergmans AM, Kluytmans JA. The cost-effectiveness of ESBL detection: towards molecular detection methods? Clin Microbiol Infect. 2013 Jul;19(7):622-5. Learn more

Bogaerts P, Sel E, Berhin C, de Mendonca R, Rodriguez-Villalobos H, Struelens MJ and Glupczynski Y. Evaluation of a DNA-based Low Density Microarray Method for the Detection and Identification of ESBL in Enterobacteriaceae. Poster session presented at: 49th ICAAC; 2009 Sept 12-15; San Francisco, US. Learn more

Leverstein-van Hall MA, Dierikx CM, Cohen Stuart J, Voets GM, van den Munckhof MP, van Essen-Zandbergen A, Platteel T, Fluit AC, van de Sande-Bruinsma N, Scharinga J, Bonten MJ, Mevius DJ; on behalf of the national ESBL surveillance group. Dutch patients, retail chicken meat and poultry share the same ESBL genes, plasmids and strains. Clin Microbiol Infect. 2011 Jun;17(6):873-80. Learn more


Check&Trace Salmonella

Publications

Aarts HJ, Vos P, Larsson JT, van Hoek AH, Huehn S, Weijers T, Grønlund HA, Malorny B. A multiplex ligation detection assay for the characterization of Salmonella enterica strains. Int J Food Microbiol. 2011 Mar 1;145 Suppl 1:S68-78. Learn more

Wattiau P, Van Hessche M, Schlicker C, Vander Veken H, Imberechts H. Comparison of classical serotyping and PremiTest assay for routine identification of common Salmonella enterica serovars. J Clin Microbiol. 2008 Dec;46(12):4037-40. Learn more

Koyuncu S, Andersson G, Vos P, Häggblom P. DNA microarray for tracing Salmonella in the feed chain. Int J Food Microbiol. 2011 Mar 1;145 Suppl 1:S18-22. Learn more

Wattiau P, Weijers T, Andreoli P, Schliker C, Veken HV, Maas HM, Verbruggen AJ, Heck ME, Wannet WJ, Imberechts H, Vos P. Evaluation of the Premi Test Salmonella, a commercial low-density DNA microarray system intended for routine identification and typing of Salmonella enterica. Int J Food Microbiol. 2008 Apr 30;123(3):293-8. Learn more

Wattiau P, Boland C, Bertrand S. Methodologies for Salmonella enterica ssp enterica subtyping: gold standards and alternatives. Appl Environ Microbiol. 2011 Nov;77(22):7877-85. Learn more

Madajczak G, Szych J. Evaluation of PremiTest Salmonella kit for identification of not-typable by conventional methods Salmonella. Med Dosw Mikrobiol. 2010;62(1):29-36. [Article in Polish]


Posters

Moury F, Fremy S, van Santen R, Imberechts H, Wattiau P, Giles M, Malorny B, Clerico Lera M, Maas H, Fabre JM, Brisabois A. Interlaboratory study of a DNA Microarray for Salmonella Molecular Serotyping in acomparison to the conventional serotyping method. Poster session presented at: I3S - International Symposium Salmonella and Salmonellosis; 2010 Jun 29- 29; Saint-Malo, France. Learn more

Brisabois A, Kérouanton, van Santen R, Fremy S, Dekker A, Moury F, Marault M, Fabre JM, Vos P, Thijssen J. Salmonella Molecular Serotyping with a DNA Microarray: an Approach for non Agglutinable Salmonella enterica Serotypes. Poster session presented at: ICEID; 2008 Mar 16-19; Atlanta; US. Learn more

Hansen F, Jacobsen T, Mansdal S. Short Evaluation of the Premi®Test Salmonella Method. Poster session presented at: Food Micro; 2010 Aug 30-Sept 3; Copenhagen, Denmark. Learn more

Brisabois A. Fremy S, Moury F, Marault M, van Santen R, Dekker A, Fabre JM, Vos P, de Goeijen F. The Effect of the Culture Medium on the Performance of the Premi®Test Salmonella: A Multiplex Molecular Serotyping Test using a DNA Microarray System. Poster session presented at: 4th Med-Vet-Net; 2008 Jun 11-14; Saint-Malo, France. Learn more

Brisabois, A. Fremy S, Moury F, van Santen R, Vos P, Fabre JM, de Goeijen F. A Multiplex Molecular Serotyping Test using a DNA Microarray System as a alternative Salmonella serotyping method. Poster session presented at: Rapid Methods Europe; 2009 Jan 26-28; Noordwijk, the Netherlands. Learn more

Van Santen R, de Goeijen F, Thijssen J, Vos P. Rapid detection of Salmonella serotypes in feed and food products using the Premi®Test Salmonella. Poster session presented at: 26th Food Microbiology Symposium; 2006 Oct 14-17; University of Wisconsin-River Falls, US. Learn more

Brisabois A, Fremy S, Moury F, Marault M, van Santen R, Vos P, Fabre JM. DNA Microarray evaluation for Salmonella serotyping. Poster session presented at: 5th Med-Vet-Net; 2009 Jun 3-6; Madrid, Spain. Learn more